The effect of resistance and aerobic training on Glut2 gene expression in pancreatic tissue of type 2 diabetic rats

Introduction: The aim of this study was to investigate the effect of resistance and aerobic training on Glut2 gene expression in pancreatic tissue of type 2 diabetic rats. Method: In this experimental study, 32 male Wistar rats in the weight range of 220+20 g were selected and then divided into 4 groups (3 type 2 diabetic groups and one healthy group). Induction of diabetes was performed by nicotinamide solution and STZ. Resistance training program was performed for 12 weeks, 5 sessions per week in the form of 3 courses with 6 repetitions in each course. The aerobic exercise program was performed on the treadmill for 12 weeks, 5 sessions per week with a gradual increase in speed (18 to 26 meters per minute) and time (10 to 55 minutes). Glut2 expression was measured by Real Time PCR. Data were analyzed by independent t-test and one-way analysis of variance at the P <0.05. Results: The results showed that there was a significant difference in intergroup changes in GLUT2 levels. There was no significant difference in the expression of this gene in the study of GLUT2 levels to compare healthy control and diabetic control groups. Conclusion: It seems that aerobic training to have a positive effect on the expression gene of GLUT2 in pancreatic tissue of type 2 diabetic rats.